Simian T-Lymphotropic Virus (STcLV2PP1664) is a complex retrovirus isolated from the wild-caught bonobo (Van Brussel et al. 1998). STcLV2PP1664 is closely related to HTLV-2 retroviruses and its genomic structure is 8.9 Kb in size including LTRs of 712 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for gag, pol and env genes characteristic of retroviruses, and also, accessory genes rex and tax (both essential for viral replication and cellular transformation in infected cells), and two ORFs that encode for proteins Tof and Rof (see accessory genes), STcLV2PP1664 also displays an ORF V and the Polypurine Tract (PPT) common to all retroviruses (Van Brussel et al. 1998)



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: Y14570
Clade: Oncovirinae C-type
Cluster or genus: Deltaretrovirus
Branch or class: Class 2
Family: Retroviridae
System: LTR retroelements
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
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Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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