Avian Reticuloendotheliosis Virus (REV) is a C-type retrovirus originally described in turkeys and chickens and has also been described as an integrated in the Fowlpox virus genome. REV induces reticuloendotheliosis, a neoplastic disease of the lymphoreticular system in birds (Theilen, Zeigel and Twiehaus 1966; Franklin, Maldonado and Bose 1974; Hoelzer et al. 1980), and carries an oncogene of 1.4 Kb integrated within the env gene (Stephens et al. 1983). During the infection the virus generates two species of unintegrated linear DNA genomes of 8.3 and 5.5 Kb, which represent the virus collaborator (REV-A) and the defective oncogenic component (REV-T), respectively (Chen et al. 1981; Wilhelmsen, Eggleton and Temin 1984).

The sequence taken as a representative to describe the genomic structure of REV, is 8 Kb in size including LTRs of 511 and 250 nt, respectively. The internal region displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for gag-pol, and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Hertig et al. 1997; Moore et al. 2000; Kim and Tripathy 2001; Singh, Schitzlein and Tripathy 2003; Garcia et al. 2003; Tadese and Reed 2003).



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: AF246698
Clade: Undetermined
Cluster or genus: Gammaretrovirus
Branch or class: Class 1
Family: Retroviridae
System: LTR retroelements
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
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Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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