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Murine Leukemia Virus (MuLV), occurring in mice is a C-type retrovirus that can be divided into four classes (Herr 1984; Stoye and Coffin 1987;O' Neill et al. 1985) according to the following host ranges:

  • Ecotropic MLVs, which infect mouse cells and are horizontally and vertically transmitted in Mus musculus
  • Polytropic MLVs, and modified polytropic MLVs, both usually isolated from leukemogenic tissues and capable of infecting mouse cells, and the cells of other organisms
  • Xenotropic MLVs, unable to proliferate in mouse cells by infection but capable of infecting cells of other species

The xenotropic DG-75 MLV is taken as a representative, its genome is 8.2 Kb size including Pro-5´LTR and Pro-3´LTR of 143 and 471 nt, respectively. The internal region of this retrovirus displays two possible tRNA Primer Binding Sites (PBS) identified in genbank accession as Y=T and S=C for a tRNAThr; and Y=C and S=G for a tRNAGlu-2, a single Open Reading Frame (ORF) gag-pol, an ORF for env gene, and also a Polypurine Tract (PPT) adjacent to the 3´LTR (Raisch et al. 2003).



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: AF221065
Clade: Undetermined
Cluster or genus: Gammaretrovirus
Branch or class: Class 1
Family: Retroviridae
System: LTR retroelements
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
Cite this project:

Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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