Murine Endogenous Retrovirus-Leucine (MuERV-L) is an endogenous env-defective retrovirus characterized in the genome of Mus musculus (Benit et al. 1997; 1999). This element belongs to the group of ERV-L elements, and its genomic structure is 6.5 Kb in size including LTRs of 493. Its internal region displays a Primer Binding Site (PBS) complementary to a tRNALeu, Open Reading Frames (ORFs) for gag and pol-dUTPase, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Benit et al. 1997; 1999).
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
||DU or DUT=dUTPase
||TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
||PBS=primer binding site
||ATF=aphid transmission factor
||VAP=virion associated protein