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Feline Leukemia Virus (FeLV) is a retrovirus characterized in the domestic cat and originally isolated in 1964. The following subgroups have been detected from a sequence variation in the viral surface env-like Surface glycoprotein (Chen et al. 1998 and references therein):

  1. FeLV-A is an ecotropic virus present in all natural isolates.
  2. FeLV-B is a polytropic virus concurrent with FeLV-A, which is over-represented in the lymphosarcomas of infected but otherwise healthy cats.
  3. FeLV-C is also polytropic, although more infrequent and related to FeLV-A or FeLV-A/plus/FeLV-B. It is known that this variant induces aplasmatic anemia in cats, and it has been speculated that this subgroup might be a variant of FeLV-A.

The "FeLV-A Rickard" strain is taken as a representative. Its genomic structure is 8.4 Kb size including LTRs of 0.5 Kb. The internal region displays a Primer Binding Site (PBS) complementary to a tRNAPro, a single Open Reading Frame (ORF) encoding the gag-pol polyproteins, an ORF for the env, and also a Polypurine Tract (PPT) adjacent to the 3′LTR (Chen et al. 1998).



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: NC_001940
Clade: Undetermined
Cluster or genus: Gammaretrovirus
Branch or class: Class 1
Family: Retroviridae
System: LTR retroelements
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
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Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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