Revision as of 08:38, 4 May 2010 by imported>Gydbwiki
Baboon Endogenous Virus (BaEVM) is a C-type endogenous retrovirus that occurs in Old World apes. BAEVM was originally isolated in mandrill cellular cultures (Beneviste et al. 1974; Todaro et al. 1974) and is detectable in placental tissue (Todaro, Sherr and Beneviste 1976). The genome of BaEVM strain M7 is taken as a representative. The genomic structure of this retrovirus is 8.5 Kb size including LTRs of 0.55 Kb, its internal region displays a Primer Binding Site (PBS) complementary to a tRNAPro, three Open Reading Frames (ORFs) for gag, pol and env genes characteristic of retroviruses; and a Polypurine Tract (PPT) adjacent to the 3′LTR ( Kato et al. 1987).
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
||DU or DUT=dUTPase
||TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
||PBS=primer binding site
||ATF=aphid transmission factor
||VAP=virion associated protein