Description
Moose is a LTR retrotransposon described in the genome of the malaria transmitting mosquito Anopheles gambiae (Biessmann et al. 1999). Moose belongs to the Bel clade (Copeland et al. 2005) within Branch 1 of the Bel/Pao family (Llorens et al. 2009).
The genome of Moose is about of 6 Kb in size (5983 bp in lenght). The internal coding region, flanked by LTRs of 265 nt, displays three ORFs encoding for gag and pol polyproteins. The gag contains the three putative Cys-motifs characteristic of the gag associated nucleocapsid domain, while pol clearly presents the protease, the reverse transcriptase, the RNase H and the integrase domains (Biessmann et al. 1999).
Structure
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
| MA=matrix
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PR=protease
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DU or DUT=dUTPase
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TM=transmembrane
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TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
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| CA=capsid
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RT=reverse transcriptase
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INT=Integrase
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CHR=chromodomain
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| NC=nucleocapsid
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RH=RNaseH
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SU=surface
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MOV=movement protein
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| PPT=polypurine tract
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PBS=primer binding site
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ATF=aphid transmission factor
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VAP=virion associated protein
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Related literature
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