Description
Mdg3 is a LTR retrotransposon described in the genome of Drosophila melanogaster (Ilyin et al. 1985). Mdg3 belongs, along with other Ty3/Gypsy LTR retrotransposons, to Micropia/mdg3 clade (Malik and Eickbush 1999). The genomic structure of mdg3 is 5.5Kb in size including LTRs with a size oscillating between 267 and 293 nt (depending on the mdg3 variant). The internal region of this element displays a Primer Binding Site (PBS), a single Open Reading Frame (ORF) that codifies for a gag-pol polyprotein, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Ilyin et al. 1985; Dzhumgaliev et al. 1986; Avedisov and Il'in,Iu. 1995).
Structure
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
| MA=matrix
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PR=protease
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DU or DUT=dUTPase
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TM=transmembrane
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TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
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| CA=capsid
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RT=reverse transcriptase
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INT=Integrase
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CHR=chromodomain
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| NC=nucleocapsid
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RH=RNaseH
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SU=surface
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MOV=movement protein
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| PPT=polypurine tract
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PBS=primer binding site
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ATF=aphid transmission factor
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VAP=virion associated protein
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Related literature
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