Description
HMS-Beagle is a LTR retrotransposon described from sequencing data in the left arm of chromosome 2 of Drosophila melanogaster (Patel et al. 2001). This element belongs to the genus Errantiviridae (Boeke et al. 1999; Pringle 1998; 1999; Hull 1999), a lineage of fly-retroviruses and LTR retrotransposons closely related to 412/mdg1 clade (Tubio, Naveira and Costas 2005).The genomic structure of HMS-Beagle is 7 Kb in size including LTRs of 266 nt. The internal region of this element displays a Primer Binding Site for a tRNALys, two ORFs for gag, and pol genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Patel et al. 2001).
Structure
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
| MA=matrix
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PR=protease
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DU or DUT=dUTPase
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TM=transmembrane
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TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
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| CA=capsid
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RT=reverse transcriptase
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INT=Integrase
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CHR=chromodomain
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| NC=nucleocapsid
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RH=RNaseH
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SU=surface
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MOV=movement protein
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| PPT=polypurine tract
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PBS=primer binding site
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ATF=aphid transmission factor
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VAP=virion associated protein
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Related literature
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