Description
Burdock is an active LTR retrotransposon originally detected in the cut locus of different ct-lethal Drosophila melanogaster mutants (Tchurikov et al. 1989). There are about 100 copies of Burdock in the Drosophila genome these varying in length from 1 to 6.4 Kb. Burdock belongs to the genus Errantiviridae (Boeke et al. 1999; Pringle 1998; 1999; Hull 1999), a lineage of fly-retroviruses and LTR retrotransposons phylogenetically related to 412/mdg1 clade (Tubio, Naveira and Costas 2005). The genomic structure of Burdock is 6.4 Kb in size, including LTRs of 275 nt. The internal region displays a Primer Binding Site complementary to a tRNALys, two ORF for gag and pol genes, and also, a Polypurine Tract (PPT) adjacent to the 3´LTR (Tchurikov et al. 1989).
Structure
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
| MA=matrix
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PR=protease
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DU or DUT=dUTPase
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TM=transmembrane
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TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
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| CA=capsid
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RT=reverse transcriptase
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INT=Integrase
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CHR=chromodomain
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| NC=nucleocapsid
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RH=RNaseH
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SU=surface
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MOV=movement protein
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| PPT=polypurine tract
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PBS=primer binding site
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ATF=aphid transmission factor
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VAP=virion associated protein
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Related literature
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