Element:PyERV

Description Python endogenous retrovirus (PyERV) is a retrovirus originally isolated from Python species (Huder et al. 2002). PyERV belongs to genus Betaretrovirus within Retroviridae family (International Committee on the Taxonomy of Viruses -ICTV- Fauquet et al. 2005) and according to Llorens et al. 2009 is located within Class 2 of the Retroviridae family. The genomic structure of PyERV is 7.0 Kb in size, including LTRs of 330 pb approximately (Huder et al. 2002). The internal region of this element displays a Primer Binding Site (PBS) complementary to a tRNATrp, two Open Reading Frames (ORFs) coding for two gag-pol and env polyproteins (gag-pol includes the dUTPase-protease characteristic of betaretroviruses) and a Polypurine Tract (PPT) adjacent to the 3´LTR (Huder et al. 2002). PyERV also shows an additional ORF (Huder et al. 2002) overlaping gag-pol, which was later identified as the typical ORFX of betaretroviruses (Llorens et al. 2008). For simplicity´s sake, the figure below shows an idealized single genomic organization) as the internal coding region of PyERV is disrupted by several stop codons and frameshiftings (see also, Huder et al. 2002). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997)

Genbank accession: 26006403 Clade: Undetermined Cluster or genus: Betaretrovirus Branch or class: Class 2 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Phyton molurus Image, Laura Covelli, Copyright, GyDB, Biotech Vana Browse all elements