Element:PERV-MSL

Description Porcine Endogenous Retrovirus (PERV-MSL) is a simple retrovirus isolated from lymphocytes of miniature swine. Constitutive production of PERV-MSL RNAs has been detected in normal leukocytes and in multiple organs of swine. The copy numbers of full-length PERV sequences per genome (approximately 8 to 15) vary among swine strains (Akiyoshi et al. 1998). Phylogenetically, PERV-MSL belongs to the genus Gammaretrovirus and is morphologically consistent with mammalian C-type retroviruses. The genomic structure of PERV-MSL is 8.13 Kb size including LTRs of 564 and 458 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for the gag, pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Akiyoshi et al. 1998). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997)

Genbank accession: AF038600 Clade: Undetermined Cluster or genus: Gammaretrovirus Branch or class: Class 1 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Sus scrofa Image, Daniela Bezemer, HIV monitoring Browse all elements