Element:Mdg1

Description Mdg1 is a LTR retrotransposon described in Drosophila melanogaster (Ilyin et al. 1980a; 1980b; Kulguskin, Ilyin and Georgiev 1981; Avedisov, Cherkasova and Il'in,Iu. 1990). Mdg1 is similar to 412 and belongs to 412/mdg1 clade (Malik and Eickbush1999). Phylogenetic analyses suggest that this clade is closely related to errantiviruses. 412/mdg1 integrases have been related to a single copy gene which codifies for a putative integrase protein (GIN-1) in humans and other vertebrates (Lloréns and Marín 2001). The genomic structure of mg1 is 7.4 Kb in size including LTRs of 442 nt. The internal region displays a Primer Binding Site (PBS) complementary to a tRNALys, two Open Reading Frames (ORFs) for gag and pol genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Avedisov, Cherkasova and Il'in,Iu. 1990). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Mobile DNA II. (Craig et al. 2002)

Genbank accession: X59545 Clade: 412/Mdg1 Cluster or genus: Undetermined Branch or class: Branch 2 Family: Ty3/Gypsy System: LTR retroelements Host: Explore the Tree Life Project Drosophila melanogaster Image, courtesy of Andreas Trepte, Max-Planck Institute for Molecular Genetics Browse all elements