Element:MdEV

Description Mus dunni Endogenous Retrovirus (MdEV) is a murine retrovirus originally isolated in Mus dunni wild mouse during experiments with human cells in order to obtain competent virus replicates in human transference experiments (Miller et al. 1996). MdEV is activated in response to 5-iode-2*deoxiuridine or hydrocortisone treatment. Various interference analyses have reported that MdEV, as opposed to other murine retroviruses, uses six different receptors to penetrate its host (Miller and Wolgamot 1997; Bonham, Wolgamot, and Miller 1997). The genomic structure of MdEV is 8.6 Kb in size including pro-LTRs 5′ and 3′ of 179 and 770 nt respectively. The internal region displays a Primer Binding Site (PBS) complementary to a tRNAGly, Open Reading Frames (ORFs) for gag-pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Wolgamot, Bonham and Miller 1998). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997)

Genbank accession: AF053745 Clade: Undetermined Cluster or genus: Gammaretrovirus Branch or class: Class 1 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Mus sp. Image, Joaquin Panadero, Copyright, GyDB, Biotech Vana Browse all elements