Element:GaLV

Description Gibbon Ape Leukemia Virus (GaLV) is a C-type oncogenic virus that induces myeloid leukemia in young gibbons. GaLV infects an especially large variety of cellular types in various species (Johann, Gibbons and O’Hara 1992; Hunter 1997). This evidence has been useful in developing genetic transference viral vectors in vivo and ex vivo (Miller et al. 1991; Wilson et al. 1989). The genomic structure of GaLV is 8.1 Kb size including pro-5´LTR and pro-3´LTR of 125 and 437 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for gag-pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Delassus, Sonigo and Wain-Hobson 1989). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997)

Genbank accession: M26927 Clade: Undetermined Cluster or genus: Gammaretrovirus Branch or class: Class 1 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Hylobates syndactylus Image, courtesy of David Pearce, primates.com Browse all elements