Eukaryotic chromodomains

The chromatin organization modifier (chromodomain) is a protein domain of 40-50 amino acids involved in chromatin remodeling and regulation of gene expression in eukaryotes (Koonin, Zhou and Lucchesi 1995; Cavalli and Paro 1998). Examples of chromodomains are for instance, the Drosophila melanogaster Heterochromatin Protein 1 (HP1), the Histone acetyltransferase MOF, the protein Polycomb (PC), and the Suppressor of variegation (Suvar).


Chromodomains have been identified in a variety of proteins that play a role in chromatin modification, including factors that activate and repress transcription. Several studies have demonstrated that chromodomains are responsible for chromatin targeting and for interactions between different proteins as a stand-alone protein interaction module (Cowell and Austin 1997; Strutt and Paro 1997; Lachner et al. 2001, as a RNA-binding module (Akhtar et al. 2000), and most recently, as a DNA-binding module (Bouazoune et al. 2002). Accounting that the chromodomain confers binding specificity to chromatin, these functions may in fact be interdependent (Kelley et al. 1999). Also, a second chromodomain motif termed chromoshadow domain has been described at the C-terminal end of several chromodomain-containing proteins such as HP1 (Aasland and Stewart 1995).


Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
Cite this project:

Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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