Simian Immunodeficiency Retrovirus of Macaques (SIVMAC) is a lentivirus closely related to HIV-2 in both genomic structure and sequence. SIVMAC has cytophatic effects and tropism towards CD-4 lymphocytes, and induces acquired Immunodeficiency Syndrome -AIDS- (Chakrabarti et al. 1987). The genomic structure of SIVMAC is 9.6 Kb in size including LTRs of 1 Kb (pro-5´LTR R/U5 and pro-3´LTR 3′ U3/R of 318 nt and 689 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNALys3; Open Reading Frames (ORFs) for gag, pol and env genes characteristic of retroviruses, tat and rev (both expanded in two exons) and vif (orf-q), which are three accessory genes common in other lentiviruses, vpx (orf-x), vpr (orf-r), and nef (ORF-F) accessory genes specifical of primate lentiviruses, and a Polypurine Tract (PPT) adjacent to the 3'-LTR (Chakrabarti et al. 1987).



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: Y00277
Clade: Primate lentiviruses
Cluster or genus: Lentivirus
Branch or class: Class 2
Family: Retroviridae
System: LTR retroelements
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
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Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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