Mdg1 is a LTR retrotransposon described in Drosophila melanogaster (Ilyin et al. 1980a; 1980b; Kulguskin, Ilyin and Georgiev 1981; Avedisov, Cherkasova and Il'in,Iu. 1990). Mdg1 is similar to 412 and belongs to 412/mdg1 clade (Malik and Eickbush1999). Phylogenetic analyses suggest that this clade is closely related to errantiviruses. 412/mdg1 integrases have been related to a single copy gene which codifies for a putative integrase protein (GIN-1) in humans and other vertebrates (Lloréns and Marín 2001). The genomic structure of mg1 is 7.4 Kb in size including LTRs of 442 nt. The internal region displays a Primer Binding Site (PBS) complementary to a tRNALys, two Open Reading Frames (ORFs) for gag and pol genes, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Avedisov, Cherkasova and Il'in,Iu. 1990).



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession: X59545
Clade: 412/Mdg1
Cluster or genus: Undetermined
Branch or class: Branch 2
Family: Ty3/Gypsy
System: LTR retroelements
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Drosophila melanogaster
Image, courtesy of Andreas Trepte, Max-Planck Institute for Molecular Genetics
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Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
Cite this project:

Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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