Element:JSRV

Description Jaagsiekte Sheep Retrovirus (JSRV) is a retrovirus originally reported in sheep and cattle, and is the causal agent of infectious pulmonary adenomatosis (Dungal, Gislason, and Taylor 1938; Coetzee, Els and Verwoerd 1976; Verwoerd et al. 1983; Demartini et al. 1987; Tustin et al. 1988; York et al. 1991; 1992). JSRV has also been reported in the mononuclear phagocytes and lymphocytes C and T of sheep (Holland et al. 1999). The genetic organization of this retrovirus is characteristic of type-B oncoviruses (York et al. 1992). Thus, this retrovirus belongs to the genus Betaretrovirus, which comprises both B- and D-type retroviruses. Interestingly, D-type betaretroviruses present a common surface receptor also used by the baboon and cat endogenous C-type gammaretroviruses (BaEVM, RD114), cellular infection by any of them can interfere with other D-type members, and also with BaEVM and RD114 (Chatterjee and Hunter 1980; Sommerfelt and Weiss 1990 ). This evidence seems to be related with the high similarity displayed between env polyproteins encoded by gammaretroviruses and D-type betaretroviruses, indicating that betaretroviruses and gammaretroviruses may have been involved in an ancient recombinatorial event (Sonigo et al 1986; Fauquet et al. 2005) or that they share a common ancestor (see env tree in section "phylogenies"). The genomic structure of JSRV is 7.5 Kb in size including pro-5´LTR of 126 nt and pro-3´LTR of 277 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNALys1,2, five Open Reading Frames (ORFs) for gag, dut/pro, pol, Orf-x, and env genes, and a Polypurine Tract (PPT) adjacent to the 3´ LTR (York et al. 1991; 1992; Bai et al. 1999; Elder et al. 1992; Payne and Elder 2001). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997)

Genbank accession: M80216 Clade: Undetermined Cluster or genus: Betaretrovirus Branch or class: Class 2 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Ovis sp. Image, Enrique Donat, Copyright, GyDB, Biotech Vana Browse all elements