Element:HERV-E

Description Human Endogenous Retrovirus type E (HERV-E) is a simple retrovirus (Steele et al. 1984; Repaske et al. 1985) that belongs to the genus Gammaretrovirus. Morphologically, HERV-E is consistent with mammalian C-type retroviruses, and its genomic structure is 8.8 Kb in size including LTRs of 495 and 497 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAGlu, Open Reading Frames (ORFs) for gag-pol (the RNase H ORF displays a frameshifting +1 into +3 not depicted in the figure below) and env genes characteristic of retroviruses , and also a Polypurine Tract (PPT) adjacent to the 3´LTR (Repaske et al. 1985). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997) Mobile DNA II. (Craig et al. 2002)

Genbank accession: M10976 Clade: Undetermined Cluster or genus: Gammaretrovirus Branch or class: Class 1 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Homo sapiens Image, Carlos Llorens, Copyright, GyDB, Biotech Vana Browse all elements