Element:SIVAGM

From The Gypsy Database

Description

Simian Immunodeficiency Retrovirus (SIVAGM) is a complex retrovirus described in African green monkeys and phylogenetically related to HIV-1 and other lentiviruses inductor of Acquired Immunodeficiency Syndrome (AIDS) in primates (Daniel et al. 1988; Muller et al. 1993). The genomic structure of SIVAGM is 9.8 Kb in size including LTRs of 715-710 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNALys3, Open Reading Frames (ORFs) for gag, pol and env genes characteristic of retroviruses, tat and rev (both expanded in two exons) and vif, which are three accessory genes common in other lentiviruses, vpx and nef accessory genes specifically observed in primate lentiviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Soares et al. 1997).

Structure

Sivagm.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:U58991
Clade:Primate lentiviruses
Cluster or genus:Lentivirus
Branch or class:Class 2
Family:Retroviridae
System:LTR retroelements
Host:
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Cercopithecus tantalus.gif
Cercopithecus tantalus
Image, courtesy of Marc Hauser, Cognitive Evolution Laboratory, Harvard University
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