The presence of a SCAN domain (Williams et al. 1995) define a subfamily of associated modules of C2H2 zinc finger proteins involved in protein-protein interactions (for a review see Edelstein and Collins 2005).

SCAN-A2 domain is a group of SCAN oligomerization domains (cd07936 in Conserved Domain Database) that is present at N-terminus in ZNF452/SCAND3 variants of SCAN/KRAB cellular integrases. In ZNF452/SCAND3 proteins, no additional zinc finger domain more than that of Integrase can be identified making the SCAN domain of ZNF452/SCAND3 a particular subgroup probably related with those found in lower vertebrates that are contained in large retrovirus-like polyproteins (Collins & Sander 2010; Ivanov et al. 2005). We have named it "SCAN-A2” domain because according to aminoacid sequence and length, the SCAN domain identified in ZNF452/SCAND3 C-INTs resembles more that of group A2 described in the mouse genome with a longer C-terminal extension (Edelstein and Collins 2005).

Welcome to the Gypsy Database (GyDB) an open editable database about the evolutionary relationship of viruses, mobile genetic elements (MGEs) and the genomic repeats where we invite all authors to contribute with their knowledge to improve and expand the topics.
Cite this project:

Llorens, C., Futami, R., Covelli, L., Dominguez-Escriba, L., Viu, J.M., Tamarit, D., Aguilar-Rodriguez, J. Vicente-Ripolles, M., Fuster, G., Bernet, G.P., Maumus, F., Munoz-Pomer, A., Sempere, J.M., LaTorre, A., Moya, A. (2011) The Gypsy Database (GyDB) of Mobile Genetic Elements: Release 2.0 Nucleic Acids Research (NARESE) 39 (suppl 1): D70-D74 doi: 10.1093/nar/gkq1061

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