Element:XEN1

Description Xenopus laevis endogenous retrovirus (Xen 1) is a retrovirus originally isolated from Xenopus laevis species (Kambol et al. 2003). Xen 1 belongs to genus Epsilonretrovirus within Retroviridae family (International Committee on the Taxonomy of Viruses -ICTV- Fauquet et al. 2005) and according to Llorens et al. 2009 is located within Class 1 of the Retroviridae family. The genome of Xen 1 is 10.2 Kb, including 5' and 3' LTRs of 550 and 548 bp in length, respectively, (Kambol et al. 2003). The internal region of this element displays a Primer Binding Site (PBS) complementary to a tRNALys2, seven Open Reading Frames (ORFs) that code for two accessory ORFs, gag, pol (PR-RT-RNase H-INT) polyprotein domains, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Kambol et al. 2003). Structure Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean: MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein Related literature Retroviruses. (Coffin, Hugges and Varmus 1997)

Genbank accession: 190336491 Clade: Undetermined Cluster or genus: Epsilonretrovirus Branch or class: Class 1 Family: Retroviridae System: LTR retroelements Host: Explore the Tree Life Project Xenopus laevis Wikimedia, courtesy of Michael Linnenbach Browse all elements