Element:XEN1

From The Gypsy Database

Description

Xenopus laevis endogenous retrovirus (Xen 1) is a retrovirus originally isolated from Xenopus laevis species (Kambol et al. 2003). Xen 1 belongs to genus Epsilonretrovirus within Retroviridae family (International Committee on the Taxonomy of Viruses -ICTV- Fauquet et al. 2005) and according to Llorens et al. 2009 is located within Class 1 of the Retroviridae family.

The genome of Xen 1 is 10.2 Kb, including 5' and 3' LTRs of 550 and 548 bp in length, respectively, (Kambol et al. 2003). The internal region of this element displays a Primer Binding Site (PBS) complementary to a tRNALys2, seven Open Reading Frames (ORFs) that code for two accessory ORFs, gag, pol (PR-RT-RNase H-INT) polyprotein domains, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Kambol et al. 2003).

Structure

XEN1.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:190336491
Clade:Undetermined
Cluster or genus:Epsilonretrovirus
Branch or class:Class 1
Family:Retroviridae
System:LTR retroelements
Host:
Explore the Tree Life Project
Xenopus.jpg
Xenopus laevis
Wikimedia, courtesy of Michael Linnenbach
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