From The Gypsy Database


Walleye Dermal Sarcoma Virus (WDSV) is a complex fish retrovirus characterized in Stizostedion vitreum (walleye). WDSV is responsible for a skin tumour called walleye dermal sarcoma that produces seasonal lesions that appear in the winter and disappear in the summer (Bowser et al. 1988; Martineau et al. 1990; Martineau et al. 1992). Phylogenetically, WDSV is close to gammaretroviruses which usually are simple retroviruses. However, WDSV has several accessory genes and is therefore, a complex retrovirus constituting an own genus. The genomic structure of WDSV genome is 12.7 Kb size including pro-LTRs of 151 nt and 1.034 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAHis, Open Reading Frames (ORFs) for gag-pol, and env genes characteristic of retroviruses, three accessory genes named OrfA (cicline-related), OrfB, and OrfC, this latter located between the U5 and gag gene, and also, a Polypurine Tract (PPT) adjacent to the 3´ LTR (Holzschu et al. 1995; Lapierre, Casey and Holzschu 1998 , Coffin, Hugges and Varmus, Map 13 1997).



Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:AF033822
Cluster or genus:Epsilonretrovirus
Branch or class:Class 1
System:LTR retroelements
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Stizostedion vitreum.gif
Stizostedion vitreum
Image, Courtesy of Aquaria Central
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