Element:PERV-MSL

From The Gypsy Database

Description

Porcine Endogenous Retrovirus (PERV-MSL) is a simple retrovirus isolated from lymphocytes of miniature swine. Constitutive production of PERV-MSL RNAs has been detected in normal leukocytes and in multiple organs of swine. The copy numbers of full-length PERV sequences per genome (approximately 8 to 15) vary among swine strains (Akiyoshi et al. 1998). Phylogenetically, PERV-MSL belongs to the genus Gammaretrovirus and is morphologically consistent with mammalian C-type retroviruses. The genomic structure of PERV-MSL is 8.13 Kb size including LTRs of 564 and 458 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for the gag, pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Akiyoshi et al. 1998).

Structure

Perv-msl.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:AF038600
Clade:Undetermined
Cluster or genus:Gammaretrovirus
Branch or class:Class 1
Family:Retroviridae
System:LTR retroelements
Host:
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