Element:MuERV-L

From The Gypsy Database

Description

Murine Endogenous Retrovirus-Leucine (MuERV-L) is an endogenous env-defective retrovirus characterized in the genome of Mus musculus (Benit et al. 1997; 1999). This element belongs to the group of ERV-L elements, and its genomic structure is 6.5 Kb in size including LTRs of 493. Its internal region displays a Primer Binding Site (PBS) complementary to a tRNALeu, Open Reading Frames (ORFs) for gag and pol-dUTPase, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Benit et al. 1997; 1999).

Structure

Muerv-l.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:Y12713
Clade:ERV-L
Cluster or genus:Undetermined
Branch or class:Class 3
Family:Retroviridae
System:LTR retroelements
Host:
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Mus musculus.gif
Mus musculus
Image, Joaquin Panadero, Copyright, GyDB, Biotech Vana
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