Description
Mtanga is a Ty1/Copia LTR retrotransposon described in the Y chromosome of the African mosquito Anopheles gambiae (Rohr et al. 2002). It constitutes a one-single-sequence clade within Branch 2 of the Ty1/Copia LTR retrotransposons family (Llorens et al. 2009) as it has no phylogenetic relatives to date reported. The full-length Mtanga genome is 4284 bp in size, including two identical 119-bp LTRs that flanked an internal region containing a Primer Binding Site (PBS) for a tRNAMet, two overlapping Open Reading Frames (ORFs) and a Polypurine Tract (PPT). The first ORF contains the gag and protease domains while the second presents the integrase, the reverse transcriptase and the RNase H domains typical of Ty1/Copia polyproteins (Rohr et al. 2002).
Structure
Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:
| MA=matrix
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PR=protease
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DU or DUT=dUTPase
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TM=transmembrane
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TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
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| CA=capsid
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RT=reverse transcriptase
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INT=Integrase
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CHR=chromodomain
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| NC=nucleocapsid
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RH=RNaseH
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SU=surface
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MOV=movement protein
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| PPT=polypurine tract
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PBS=primer binding site
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ATF=aphid transmission factor
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VAP=virion associated protein
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Related literature
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