Element:Moose

From The Gypsy Database

Description

Moose is a LTR retrotransposon described in the genome of the malaria transmitting mosquito Anopheles gambiae (Biessmann et al. 1999). Moose belongs to the Bel clade (Copeland et al. 2005) within Branch 1 of the Bel/Pao family (Llorens et al. 2009). The genome of Moose is about of 6 Kb in size (5983 bp in lenght). The internal coding region, flanked by LTRs of 265 nt, displays three ORFs encoding for gag and pol polyproteins. The gag contains the three putative Cys-motifs characteristic of the gag associated nucleocapsid domain, while pol clearly presents the protease, the reverse transcriptase, the RNase H and the integrase domains (Biessmann et al. 1999).

Structure

Moose.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:3347855
Clade:Bel
Cluster or genus:Undetermined
Branch or class:Branch 1
Family:Bel/Pao
System:LTR retroelements
Host:
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Anopheles gambiae.jpg
Anopheles gambiae
Courtesy of James D. Gathany, CDC
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