Element:LPDV

From The Gypsy Database

Description

Lymphoproliferative Disease Virus (LPDV) is a retrovirus that induces an acute, horizontally transmitted turkey disease that is often fatal (Gazit et al. 1979; Yaniv et al. 1979). LPDV represents a distinct group of avian retroviruses closely related to avian sarcoma-leukemia viruses (Chajut et al. 1992). The genomic structure of LPDV is 7.1 Kb in size including pro-LTRs of 118 and 257 nt. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNATrp, Open Reading Frames (ORFs) for gag, pro, pol, and env genes characteristic of retroviruses, four small ORFs whose function is unclear, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Gak et al. 1991; Sarid et al. 1994).

Structure

Lpdv.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:U09568
Clade:Undetermined
Cluster or genus:Alpharetrovirus
Branch or class:Class 2
Family:Retroviridae
System:LTR retroelements
Host:
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Meleagris gallopavo.gif
Meleagris gallopavo
Image, courtesy of Cal Vornberger
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