Element:KoRV

From The Gypsy Database

Description

Koala Retrovirus (KoRV) is a C-type retrovirus detected by electron microscopy in mitogen-stimulated peripheral blood mononuclear cell cultures and lymphoma tissues (Hanger et al. 2000). Both complete and apparently truncated pro-retroviruses have been detected in DNA of clinically normal koalas and those with hemaetopoietic disease. Phylogenetically, KoRV belongs to the genus Gammaretrovirus, and is morphologically consistent with the mammalian C-type retroviruses. The genomic structure of KoRV is 8.4 Kb size including LTRs of 0.55 Kb. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAPro, Open Reading Frames (ORFs) for the gag, pol and env genes characteristic of retroviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Hanger et al. 2000).

Structure

Korv.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:AF151794
Clade:Undetermined
Cluster or genus:Gammaretrovirus
Branch or class:Class 1
Family:Retroviridae
System:LTR retroelements
Host:
Explore the Tree Life Project
Phascolarctos cinereus.gif
Phascolarctos cinereus
Image, copyright of Bryce Lane, courtesy of Chris Glenn, JC Raulston Arboretum
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