Element:HERV-E

From The Gypsy Database

Description

Human Endogenous Retrovirus type E (HERV-E) is a simple retrovirus (Steele et al. 1984; Repaske et al. 1985) that belongs to the genus Gammaretrovirus. Morphologically, HERV-E is consistent with mammalian C-type retroviruses, and its genomic structure is 8.8 Kb in size including LTRs of 495 and 497 nt, respectively. The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNAGlu, Open Reading Frames (ORFs) for gag-pol (the RNase H ORF displays a frameshifting +1 into +3 not depicted in the figure below) and env genes characteristic of retroviruses , and also a Polypurine Tract (PPT) adjacent to the 3´LTR (Repaske et al. 1985).

Structure

Herv-e.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:M10976
Clade:Undetermined
Cluster or genus:Gammaretrovirus
Branch or class:Class 1
Family:Retroviridae
System:LTR retroelements
Host:
Explore the Tree Life Project
Homo sapiens.gif
Homo sapiens
Image, Carlos Llorens,
Copyright, GyDB, Biotech Vana
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