Element:CAEV

From The Gypsy Database

Description

Caprine Arthritis Encephalitis Virus (CAEV) is a lentivirus closely related to Visna lentiviruses. This retrovirus was originally reported from a case of leuko-encephalitis described in lambs (Cork et al. 1974; Crawford et al. 1980; Adams et al. 1980). CAEV is the etiologic agent of an inflammatory disease that occurs in domestic goats and primarily characterized by chronic arthritis and mastitis in adults, and leukoencephalomyelitis in young animals (see review Narayan et al. 1993).

The genomic structure of CAEV is 9.2 Kb in size including LTRs of approximately 534 nt (pro 5´LTR-R/U5 and pro 3´LTR-U3/R of 163 and 371 nt). The internal region of this retrovirus displays a Primer Binding Site (PBS) complementary to a tRNALys, Open Reading Frames (ORFs) for gag, pol, and env genes characteristic of retroviruses, tat and rev and orfq (vif or sor), which are three accessory genes common in other lentiviruses, an orfw also displayed but corrupted in other sheep lentiviruses, and a Polypurine Tract (PPT) adjacent to the 3´LTR (Sherman et al. 1986; Saltarelli et al. 1990; Kalinski et al. 1991; Saltarelli et al. 1993; Kalinski et al. 1994; Saltarelli et al. 1994; Wain-Hobson et al. 1995). As other non-primate lentiviruses, CAEV displays between the RNase H and INT domains, an ORF coding for a dUTPase similar to that observed in betaretroviruses, N-terminal to the PR domain (Elder et al. 1992; Payne and Elder 2001 and references therein).

Structure

Caev.png


Figure not to scale. If present, long terminal repeats (LTRs) have been highlighted in blue. Amino acid motifs noted with lines indicate the conserved residues in each protein domain, abbreviations below mean:

MA=matrix PR=protease DU or DUT=dUTPase TM=transmembrane TAV or IBMP=transactivator/viroplasmin or inclusion body matrix protein
CA=capsid RT=reverse transcriptase INT=Integrase CHR=chromodomain
NC=nucleocapsid RH=RNaseH SU=surface MOV=movement protein
PPT=polypurine tract PBS=primer binding site ATF=aphid transmission factor VAP=virion associated protein

Related literature

Genbank accession:M33677
Clade:Ovine/Caprine lentiviruses
Cluster or genus:Lentivirus
Branch or class:Class 2
Family:Retroviridae
System:LTR retroelements
Host:
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Capra pyrenaica.gif
Capra pyrenaica
Image, copyright of Jorge Aguilar Bosch, by courtesy of Margarita Lopez, SESBE
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